HISTORY
The interest in hydroxychloroquine as a potential cure for COVID-19 began on March 16th when Long Island attorney Gregory Riganoit promoted on the Laura Ingram FOX News. He was advocating for a sloppy paper by the eminent French microbiologist Didier Raoult
Sean Hannity
began promoting it as a cure for Covid-19.
Rigano appeared on Tucker
Carlson’s show and claimed that Raoult’s study had shown
hydroxychloroquine to have a “100 percent cure rate against
coronavirus.” According to Todaro, Raoult had sent him a copy of his
study and allowed him to post it on Twitter that day, two days before
the preprint release.
Later, Raoult
himself appeared on “Dr. Oz,” a frequent Fox News guest who has promoted
hydroxychloroquine.
Donald Trump
began hyping hydroxychloroquine on March 19, at a White House news
conference with his coronavirus task force. He suggested, inaccurately,
that the F.D.A. had approved the drug for use against Covid-19.
The F.D.A.,
under what appears to have been strong pressure from the Trump
administration, issued an emergency-use authorization for chloroquine
phosphate and hydroxychloroquine sulfate,
Unusually, the C.D.C., at what was reportedly Trump’s direct urging,
issued Covid-19 prescription guidelines for the drugs based upon
unattributed clinical anecdotes. (The guidelines were later withdrawn.)
A
top government biomedical official was removed from his post, he has
claimed, for having resisted political pressure to fund “potentially
dangerous drugs,” including hydroxychloroquine.
https://www.nytimes.com/2020/05/12/magazine/didier-raoult-hydroxychloroquine.html
JUNE18, 2020
Food and Drug Administration chief scientist Denise Hinton wrote to Gary Disbrow of the Biomedical Advanced Research and Development Authority on Monday that the agency had "concluded that, based on [n]ew information . . . . it is no longer reasonable to believe that oral formulations of [hydroxychloroquine sulfate] and [chloroquine phosphate] may be effective in treating COVID-19, nor is it reasonable to believe that the known and potential benefits of these products outweigh their known and potential risks."
As a result of that conclusion, the FDA revoked its emergency use authorization for the drugs, meaning that hydroxychloroquine can no longer be made available as a novel coronavirus treatment despite having not been officially approved.
Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Henry Ford Health System Study Shows July 02, 2020
DETROIT – Treatment with hydroxychloroquine cut the death rate significantly in sick patients hospitalized with COVID-19 – and without heart-related side-effects, according to a new study published by Henry Ford Health System.
https://wattsupwiththat.com/2020/07/03/good-quality-paper-demonstrates-strong-efficacy-of-hydroxychloroquine-mortality-rate-cut-in-half/
International Journal of Infectious Diseases
https://www.ijidonline.com/article/S1201-9712(20)30534-8/fulltext
NOT SO FAST
In the global context, this study is thought-provoking, with results that are in opposition to other large US cohorts/. It remains fundamentally limited by its observational nature and is subject to residual confounding. The published results of the UK RECOVERY and WHO Solidarity trials are expected to conclude that hydroxychloroquine does not decrease mortality in hospitalized COVID-19 patients when compared to standard of care.. Given the current polarized opinions surrounding hydroxychloroquine, there will likely be a lot of energetic discussion following their eventual publication.
https://www.ijidonline.com/article/S1201-9712(20)30530-0/fulltext
OTHER
WHIP Study https://clinicaltrials.gov/ct2/show/NCT04341441
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